Laboratory

Benjamin, K. 2024. Make training easier with a scruffing restraint device. Laboratory Animal Science Professional 12(2) (March/April), 38-39.

If you conduct technical training with mice at your institution, a scruffing restraint device is a valuable addition to your training aid tool kit. A scruffing restraint device, such as the ScruffGuard offered by Research...

Wongsaengchan, C., McCafferty, D. J., Lennox, K. et al. 2023. Non-invasive assessment of positive affective state using infra-red thermography in rats. Animal Welfare 32, e66.

With recent increased focus on positive welfare in animal welfare science, there is demand for objective positive welfare indicators. It is unclear whether changes in body surface temperature can be used to non-invasively identify and...

Walczak-Gillies, Matthews, O., Fyfe, A. et al. 2023. Refining the welfare of immunocompromised mice receiving carbon tetrachloride (CCI4) to induce liver fibrosis. Animal Technology and Welfare 22(3), 237–239.

Our method provides evidence that we can alter CCI4 dosing and implement recovery techniques to enhance Animal Welfare, whilst maintaining sufficient levels of fibrosis in the liver.

Rawle, F. 2023. The role of review and regulatory approvals processes for animal research in supporting implementation of the 3Rs. Animal Technology and Welfare 22(3), 175–188.

The NC3Rs commissioned this work towards the end of 2021, based on a concern that advances in the 3Rs often take a long time to come into routine use. Most research in the academic sector...

Rashbrook, V. S., Denti, L., Ruhrberg, C. 2023. Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia. Animal Welfare 32, e78.

Tamoxifen-induced CreER-LoxP recombination is often used to induce spatiotemporally controlled gene deletion in genetically modified mice. Prior work has shown that tamoxifen and tamoxifen-induced CreER activation can have off-target effects that should be controlled. However...

Matthews, B., New, R., Kanse, Y. M. et al. 2023. Cooped up: Refinement of a Gallus gallus domesticus environment. Animal Technology and Welfare 22(3), 228–230.

Providing an enriched species specific environment, coupled with the principles of the 3Rs (Refinement, Reduction and Replacement) is at the heart of the poulty team team at The Pirbright Institute. Periodically reviwed custom made cage...

Laniyan, F., Pearce, C., Hammonds, J. et al. 2023. The benefit of study plans to facility management. Animal Technology and Welfare 22(3), 244–245.

The introduction of the study plans has been a great positive for research at KCL by ensuring compliance and helping to promote the principles of the 3Rs. They have helped prevent non-compliance and given the...

Krueger, J. C., Habigt, M. A., Helmedag, M. J. et al. 2023. Evaluation of score parameters for severity assessment of surgery and liver cirrhosis in rats. Animal Welfare 32, e29.

Severity assessment in animals is an ongoing field of research. In particular, the question of objectifiable and meaningful parameters of score-sheets, as well as their best combination, arise. This retrospective analysis investigates the suitability of...

Hickman, M., Miller, L., MacDonald, R. 2023. An assessment of rat hammocks as enrichment. Animal Technology and Welfare 22(3), 221–223.

Research has shown there are numerous welfare and scientific benefits to housing rats in more enriched and environmentally complex housing opposed to conventional housing. With the aim of increasing environmental complexity, providing opportunities for climbing...

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