Includes refinements to animal models of aging, asthma, cancer, colitis, diabetes, epilepsy, polyarthritis, etc.
Pre- and post-surgical care includes providing the animals with a soft version of their standard Irradiated diet. Food pellets are soaked in sterile water and this turns into a mash. This ensures that the animals...
This article will discuss an improved and refined technique used for working and caring for a group of diabetic mice. As a team of animal technologists, academics and named veterinary surgeon, we developed a new...
The RSPCA/UFAW Rodent (and now Rabbit) Welfare Group held a one-day meeting on 1 November 2016 at the University of Edinburgh and was attended by 70 delegates. Presentation topics included refinements in blood sampling rodents...
Provision of liquid enteral nutrition (LEN) during the perioperative period is standard practice for rodents undergoing bariatric surgery, yet these diets are associated with several challenges, including coagulation of the liquid diet within the delivery...
One of 2 models required by the U.S. Food and Drug Administration for registration of a treatment for osteoporosis, the ovariectomized (OVX) rat model, is widely used in scientific studies investigating sex hormone-deficient bone loss...
In recent years, the use of hormonal contraception in captive, free-ranging, and wild mammal populations has increased, but the effects on these nonhuman animals’ behavior and the associated welfare impacts remain poorly understood. This study...
Transgenic tumour necrosis factor alpha (TNFα)-driven models of polyarthritis such as the TNFΔARE mouse have proven to be invaluable in delineating aspects of inflammatory disease pathophysiology in humans. Unfortunately, the onset of joint destruction and...
Inflammatory bowel diseases (IBD) are chronic relapsing disorders of the gastrointestinal tract. Several mouse models for IBD are available, but the acute dextran sulfate sodium (DSS)-induced colitis model is mostly used for preclinical studies. However...
The present article represents a consensus view of the appropriate utilization of chimpanzees in AIDS research arrived at as a result of a meeting of a group of scientists involved in AIDS research with chimpanzees...
Although rodent models are very popular for scientific studies, it is becoming more evident that large animal models can provide unique opportunities for biomedical research. Sheep are docile in nature and large in size, which...