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Whitham, J. C., Miller, L. J. 2024. Utilizing vocalizations to gain insight into the affective states of non-human mammals. Frontiers in Veterinary Science 11.

This review discusses how welfare scientists can examine vocalizations to gain insight into the affective states of individual animals. In recent years, researchers working in professionally managed settings have recognized the value of monitoring the...

Lucas, R. J., Allen, A. E., Brainard, G. C. et al. 2024. Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research. PLOS Biology 22(3), e3002535.

Light enables vision and exerts widespread effects on physiology and behavior, including regulating circadian rhythms, sleep, hormone synthesis, affective state, and cognitive processes. Appropriate lighting in animal facilities may support welfare and ensure that animals...

Louis-Maerten, E., Milford, A., Shaw, D. M. et al. 2024. Perceptions of 3R implementation in European animal research: A systematic review, meta-analysis, and meta-synthesis of barriers and facilitators. PLOS ONE 19(3), e0300031.

Objectives The purpose of this systematic review was to examine how the scientific community in Europe that is involved with research with animals perceives and experiences the implementation of 3R (Replace, Reduce, Refine). Methods A...

Grandjean, J., Lake, E. M. R., Pagani, M. et al. 2024. What N Is N-ough for MRI-based animal neuroimaging? eNeuro 11(3), ENEURO.0531-23.2024.

Fueled by the recent and controversial brain-wide association studies in humans, the animal neuroimaging community has also begun questioning whether using larger sample sizes is necessary for ethical and effective scientific progress. In this opinion...

Azilagbetor, D. M., Shaw, D., Elger, B. S. 2024. Animal research regulation: Improving decision-making and adopting a transparent system to address concerns around approval rate of experiments. Animals 14(6), 846.

The use of nonhuman animals in biomedical research is regulated under stringent conditions, not only in response to societal attitudes towards animal experimentation but also because ethical responsibility in scientific research requires researchers and veterinarians...

Schauer, L. 2023. “Human shield”, habituation, and trail implementation—The complex world of field biology. Canopy 24(1), 22–23.

My study highlighted not only the strength and complexity of the “human shield” effect, but also that trail systems, while valuable to research, need to be constructed in a way which enables the target species...

Rawle, F. 2023. The role of review and regulatory approvals processes for animal research in supporting implementation of the 3Rs. Animal Technology and Welfare 22(3), 175–188.

The NC3Rs commissioned this work towards the end of 2021, based on a concern that advances in the 3Rs often take a long time to come into routine use. Most research in the academic sector...

Laniyan, F., Pearce, C., Hammonds, J. et al. 2023. The benefit of study plans to facility management. Animal Technology and Welfare 22(3), 244–245.

The introduction of the study plans has been a great positive for research at KCL by ensuring compliance and helping to promote the principles of the 3Rs. They have helped prevent non-compliance and given the...

Hampton, J. O., Hemsworth, L. M., Hemsworth, P. H. et al. 2023. Rethinking the utility of the Five Domains model. Animal Welfare 32, e62.

The Five Domains model is influential in contemporary studies of animal welfare. It was originally presented as a conceptual model to understand the types of impact that procedures may impose on experimental animals. Its application...

Dauchy, R. T., Blask, D. E. 2023. Vivarium lighting as an important extrinsic factor influencing animal-based research. JAALAS 62(1), 3–25.

Light is an extrinsic factor that exerts widespread influence on the regulation of circadian, physiologic, hormonal, metabolic, and behavioral systems of all animals, including those used in research. These wide-ranging biologic effects of light are...

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