Consistently accurate intravenous tail vein administration of radiopharmaceuticals in anesthetized mice is a critical component of successful PET/CT imaging in the preclinical setting. Injectable anesthetics are often not suitable for PET imaging and commercially available...
Advances in bioanalytic methods allow for accurate plasma drug level measurement in small sample volumes. Decreased sample volumes enable serial blood sample collection from one rodent, rather than terminal or sparse sampling from multiple rodents...
An effort to refine rodent blood collection techniques resulted in an examination of alternative methodologies to improve animal welfare and sample quality. Disease model or repeated sample collection resulted in inadequate sample volume, occasional hemolysis...
Obtaining quality blood samples while minimizing animal trauma related to venipuncture continues to be an important area of focus within the laboratory animal environment as it relates to both animal welfare and sample integrity. A...
Positive reinforcement training can be used in many ways to enhance the welfare of captive primates. Training for biologic sample collection is one application of positive reinforcement training. In this study, 35 adult female chimpanzees...
Minimizing the number of animals in regulatory toxicity studies while achieving study objectives to support the development of future medicines contributes to good scientific and ethical practices. Recent advances in technology have enabled the development...
Traditional pharmacokinetic analysis in nonclinical studies is based on the concentration of a test compound in plasma and requires approximately 100 to 200 μL blood collected per time point. However, the total blood volume of...