Anesthesia

Eliav, A., Ofri, R., Brust, K. et al. 2024. Improving rat welfare through the development of a peribulbar anaesthesia technique for ophthalmic procedures: A preliminary study. Laboratory Animals 58(2), 116–126.

Rats are a commonly used animal model for the study of the pathogenesis and novel treatments of glaucoma, which is induced experimentally using invasive, painful procedures. Peribulbar anaesthesia (PBA) is frequently used in people and...

Cuttance, E. L., Mason, W. A., McDermott, J. et al. 2024. Comparison of three anaesthetic options to reduce acute pain response in kid goats. Journal of Applied Animal Welfare Science 27(3), 465–476.

Three options for anesthetizing the skin around the horn bud of dairy goat kids were explored. Forty-five

Cogo Pagella, J., Rodríguez, M. F., Frisina, F. et al. 2024. Combining melatonin with dexmedetomidine improves anesthesia in rats. Laboratory Animals 58(3), 277–280.

Melatonin (ML) and dexmedetomidine (DM) are used separately as anesthetic premedication or as an anesthetic in humans and laboratory animals. In this study, we aimed to investigate the anesthetic properties of both drugs combined. The...

Rashbrook, V. S., Denti, L., Ruhrberg, C. 2023. Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia. Animal Welfare 32, e78.

Tamoxifen-induced CreER-LoxP recombination is often used to induce spatiotemporally controlled gene deletion in genetically modified mice. Prior work has shown that tamoxifen and tamoxifen-induced CreER activation can have off-target effects that should be controlled. However...

Bodnar, M. J., Ratuski, A. S., Weary, D. M. 2023. Mouse isoflurane anesthesia using the drop method. Laboratory Animals 57(6), 623–630.

Anesthesia with isoflurane prior to carbon dioxide euthanasia is recommended as a refinement, but vaporizer access can be limited. An alternative to vaporizers is the ‘drop’ method, introducing a fixed volume of isoflurane into the...

Huss, M. K., Pacharinsak, C. 2022. A review of long-acting parenteral analgesics for mice and rats. JAALAS 61(6), 595–602.

Appropriate analgesia is a crucial part of rodent postoperative and postprocedural pain. Providing appropriate analgesia is an ethical obligation, a regulatory requirement, and an essential element of obtaining quality scientific results and conducting reproducible data...

Webb, J. K., Keller, K. A., Chinnadurai, S. K. et al. 2023. Use of alfaxalone in bearded dragons (Pogona vitticeps): Optimizing pharmacodynamics and evaluating cardiogenic effects via echocardiography. Journal of the American Veterinary

OBJECTIVE Bearded dragons (Pogona vitticeps), a popular zoological companion species, frequently require sedation for procedures. A novel formulation of alfaxalone with preservatives was FDA approved for 28-day use after the vial is breached. Research has...

Weaver, H. L., Carbaugh, C. M., Madejczyk, M. S. et al. 2024. Comparison of tricaine methanesulfonate (MS-222) and alfaxalone anesthesia in zebrafish (Danio rerio). JAALAS 63(1), 74–80.

The research use of zebrafish has risen exponentially over the past decade while anesthetic options have remained largely unchanged.6 ricaine methanesulfonate (MS-222) is widely accepted as an anesthetic for routine husbandry procedures, however it has...

Mumm, L. E., Mans, C. 2022. Evaluation of dexmedetomidine-midazolam sedation in budgerigars (Melopsittacus undulatus). Journal of the American Veterinary Medical Association 260(10), 1194–1199.

OBJECTIVE To evaluate the sedative effects of IM administration of a high or low dose of dexmedetomidine in combination with midazolam in budgerigars (Melopsittacus undulatus). ANIMALS 20 healthy adult budgerigars. PROCEDURES In a prospective, randomized...

Martin-Flores, M., Nugen, S. A., Boesch, J. M. et al. 2023. Low-dose epidural anesthesia decreases the use of intraoperative systemic analgesics in goats undergoing lower urinary tract surgery. Journal of the American Veterinary Medical

OBJECTIVE To test whether the use of low-dose epidural anesthesia (EA) in goats undergoing lower urinary tract surgery reduces the requirements of perioperative analgesics, contributes to intraoperative hypotension, and improves postoperative comfort during the first...

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