Includes refinements to diet, bedding or flooring, cage changing, lighting, temperature, noise levels, etc.
Laboratory animals experience a large amount of environmental stress. An animal’s environment can include both physiological and social stressors that may require an animal to adapt to maintain allostatic balance. For example, thermal stress can...
The poor record of basic-to-clinical translation in recent decades has led to speculation that preclinical research is “irreproducible”, and this irreproducibility in turn has largely been attributed to deficiencies in reporting and statistical practices. There...
Eighteen lactating dairy cows were used to elucidate their preference for green, grey, or red troughs. The herd was managed under a rotational grazing system with ad-libitum access to water until 11:30 h. For 9...
With their highly sensitive olfactory system, the behaviour and physiology of mice are not only influenced by the scents of conspecifics and other species, but also by many other chemicals in the environment. The constraints...
Olfaction plays a crucial role in mouse communication, providing information about genetic identity, physiological status of conspecifics and alerting mice to potential predators. Scents of animal origin can trigger physiological and behavioural responses that could...
As part of routine husbandry, an increasing number of laboratory mice receive nesting material in addition to standard bedding material in their cages. Nesting material improves health outcomes and physiological performance in mice that receive...
The standard housing temperature in animal facilities is substantially below the lower critical temperature of mice. This does not only endanger animal welfare, it can also jeopardize scientific research as cold stress has a major...
The Scientific Committee of the Swiss Laboratory Animal Science Association (Schweizerische Gesellschaft für Versuchstierkunde, SGV) reports on the Annual SGV Meeting held on 28 and 29 November 2017, at Technopark, Zürich, Switzerland. Feedback after the...
The streptozotocin (STZ)-induced diabetic mouse is a widely used model of diabetes and diabetic nephropathy (DN). However, it is a well-known issue that this model is challenged by high weight loss, which despite supportive measures...
Smothering, when birds group together in a way that results in death from suffocation, is a welfare and economic concern for the egg industry. This questionnaire-based study explored correlations between disease, housing, management practices and...