In management of laboratory animals, wet bedding created by mice and abnormal fur in mice cause problems on housing, leading to negative effects both on the wellbeing of mice and on the validity of experimental...
Barbering (incessant grooming) is an abnormal behavior causing alopecia and commonly affects various strains of laboratory mice, including C57BL/6J. Barbering-induced alopecia is a potential symptom of brain impairment and can indicate a stressful environment. We...
This study compared 4 bedding substrates (corncob, paper, hardwood chip, and wire-bottomed cage inserts) and 2 routes of blood collection (lateral tail vein and retroorbital sinus) in 6 male C57BL/6NCrl mice. Mice were maintained with...
In laboratories, mice are housed at 20-24C, which is below their lower critical temperature (30C). This increased thermal stress has the potential to alter scientific outcomes. Nesting material should allow for improved behavioral thermoregulation and...
Animal models of early-life stress and variation in social experience across the lifespan have contributed significantly to our understanding of the environmental regulation of the developing brain. Plasticity in neurobiological pathways regulating stress responsivity, cognition...
Stereotypic behaviors are repetitive invariant behaviors that are common in many captive species and potentially indicate compromised welfare and suitability as research subjects. Adult laboratory mice commonly perform stereotypic bar-gnawing, route-tracing, and back-flipping, although great...
Environmental enrichment aims to improve the wellbeing of laboratory animals and provides an opportunity to improve experimental reliability and validity. Animals raised in more stimulating environments have improved learning and memory as well as more...
Philosopher and ethicist Professor Bernard Rollin recently wrote that animal researchers should “do the utmost to minimise animal suffering arising in the course of animal research, and maximise the animal’s ability to live a life...
Ongoing studies and historical data support the finding that deviations or exceptions from the cage density and sanitation frequency standards set forth in the Guide do not negatively affect animal health, welfare, or production parameters...
Bedding influences various parameters in the housing of laboratory mice, such as health, physiology and behaviour (often considered as being integral parts of welfare). Notwithstanding existent studies about bedding preferences of individually tested mice, data...