The environment that laboratory animals are housed in should reflect their natural habitats in a manner that can satisfy their innate physiological and behavioural needs. This includes nest building, hiding, exploring and foraging. Providing environmental...
Recent studies have shown that the method choice for handling laboratory mice is important to animal welfare. In 2015, 60% of all animals used in Home Office procedures were laboratory mice. Given the large number...
The transportation of animals from supplier to experimental facility is one of the biggest stressors to animals in research. Transportation unavoidably causes stress and when the animals arrive at the testing facility they require a...
Since rats lack a gall bladder, they are an ideal model for investigating continuous biliary excretion and biotransformation. The design and implementation of a modified tail cuff and cannula system introduced at Covance permits the...
Common enrichment for mice is usually restricted to the floor and easily damaged, leading to frequent replacement. We have been studying the behaviour of NSG mice towards a 'swing' made from plastic cable ties. This...
Synchronisation of oestrous cycle is a commonly used method to manage pregnancies either for breeding or for research purposes. Based on Whitten effect, the aim of our study was to introduce a new refined method...
Using an existing gang cage designed for ferrets, we developed a version that would be suitable for housing rats. Caging consisted of 3 floors with a combined floor area of 11620m, connected by 2 ladders...
Recent research in the industry identified that picking up mice in a tunnel or cupping them in the hand significantly reduces their stress levels. As Animal Tecgnologists, we could see advantages and disadvantages with this...
Repeated injections in rats and mice are typically done via the tail vein. For hamsters, the tail is not an option. In this paper we explore the development and refinement of IV dosing in the...
There are varying methods used for animal restraint and angle of injection. It remains unclear whether one method is more accurate than others. The primary objectives were to examine whether inverted restraint of rats resulted...