Rodent

Wikanthi, L. S. S., Forsström, J., Ewaldsson, B. et al. 2024. Improved memory and lower stress levels in male mice co-housed with ovariectomized female mice. Animals 14(10), 1503.

Aggressiveness, expressed by fighting, is a frequent problem in group-housed laboratory male mice and results in increased stress, injury, and death. One way to prevent fighting is by pairing the male mice with ovariectomized female...

Varholick, J. A., Godinez, G., Jenkins, A. et al. 2024. Bite wounds and dominance structures in male and female African spiny mice (Acomys cahirinus): Implications for animal welfare and the generalizability of experimental results. Animals 14(1), 64

Bite wounds due to aggression in male laboratory mice (Mus musculus) are a major welfare concern, often leading to attrition, chronic activation of the innate immune system, and significant impacts on the experimental results derived...

Streiff, C., Herrera, A., Voelkl, B. et al. 2024. The impact of cage dividers on mouse aggression, dominance and hormone levels. PLOS ONE 19(2), e0297358.

Home cage aggression in group-housed male mice is a major welfare concern and may compromise animal research. Conventional cages prevent flight or retreat from sight, increasing the risk that agonistic encounters will result in injury...

Schmitt, O., Finnegan, E., Trevarthen, A. et al. 2024. Exploring the similarities between risk factors triggering depression in humans and elevated in-cage “inactive but awake” behavior in laboratory mice. Frontiers in Veterinary Science 11.

Depression is a human mental disorder that can also be inferred in non-human animals. This study explored whether time spent inactive but awake (“IBA”) in the home-cage in mice was further triggered by risk factors...

Schiele, A. R., Henze, I. S., Bettschart-Wolfensberger, R. et al. 2024. Antinociceptive and cardiorespiratory effects of a single dose of dexmedetomidine in laboratory mice subjected to craniotomy under general anaesthesia with isoflurane and carprof

Pain refinement represents an important aspect of animal welfare in laboratory animals. Refining analgesia regimens in mice undergoing craniotomy has been sparsely investigated. Here, we sought to investigate the effect of dexmedetomidine in combination with...

Sanz-Moreno, A., da Silva-Buttkus, P., Terwee, C. B. et al. 2024. Assessment of quality of life and wellbeing in mouse preclinical research – A scoping review. Neuroscience Applied 3, 104058.

Mouse preclinical research is of great scientific interest to understand the mechanisms of human diseases and test potential therapeutic interventions. Researchers characterize biological and physiological traits, behaviors and disease symptoms using standardized phenotypic protocols in...

Roschke, N. N., Hillebrandt, K. H., Polenz, D. et al. 2024. Optimizing environmental enrichment for Sprague Dawley rats: Exemplary insights into the liver proteome. PLOS ONE 19(4), e0297497.

Background Considering the expected increase in the elderly population and the growing emphasis on aging-related biomedical research, the demand for aged laboratory animals has surged, challenging established husbandry practices. Our objective was to establish a...

Nugroho, D. A. A., Kusrohmaniah, S., Pilz, E. et al. 2024. No evidence tube entrapment distresses rodents in typical empathy tests. Animal Cognition 27(1), 29.

In the first two experiments an empty tube open at one end was placed in different locations. Male hamsters, tested one at a time, tended to stay close to the tube or in it. During...

Lucas, R. J., Allen, A. E., Brainard, G. C. et al. 2024. Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research. PLOS Biology 22(3), e3002535.

Light enables vision and exerts widespread effects on physiology and behavior, including regulating circadian rhythms, sleep, hormone synthesis, affective state, and cognitive processes. Appropriate lighting in animal facilities may support welfare and ensure that animals...

Lipp, H.-P., Krackow, S., Turkes, E. et al. 2024. IntelliCage: The development and perspectives of a mouse- and user-friendly automated behavioral test system. Frontiers in Behavioral Neuroscience 17.

IntelliCage for mice is a rodent home-cage equipped with four corner structures harboring symmetrical double panels for operant conditioning at each of the two sides, either by reward (access to water) or by aversion (non-painful...

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