Rodent

Schiele, A. R., Henze, I. S., Bettschart-Wolfensberger, R. et al. 2024. Antinociceptive and cardiorespiratory effects of a single dose of dexmedetomidine in laboratory mice subjected to craniotomy under general anaesthesia with isoflurane and carprof

Pain refinement represents an important aspect of animal welfare in laboratory animals. Refining analgesia regimens in mice undergoing craniotomy has been sparsely investigated. Here, we sought to investigate the effect of dexmedetomidine in combination with...

Sanz-Moreno, A., da Silva-Buttkus, P., Terwee, C. B. et al. 2024. Assessment of quality of life and wellbeing in mouse preclinical research – A scoping review. Neuroscience Applied 3, 104058.

Mouse preclinical research is of great scientific interest to understand the mechanisms of human diseases and test potential therapeutic interventions. Researchers characterize biological and physiological traits, behaviors and disease symptoms using standardized phenotypic protocols in...

Roschke, N. N., Hillebrandt, K. H., Polenz, D. et al. 2024. Optimizing environmental enrichment for Sprague Dawley rats: Exemplary insights into the liver proteome. PLOS ONE 19(4), e0297497.

Background Considering the expected increase in the elderly population and the growing emphasis on aging-related biomedical research, the demand for aged laboratory animals has surged, challenging established husbandry practices. Our objective was to establish a...

Nugroho, D. A. A., Kusrohmaniah, S., Pilz, E. et al. 2024. No evidence tube entrapment distresses rodents in typical empathy tests. Animal Cognition 27(1), 29.

In the first two experiments an empty tube open at one end was placed in different locations. Male hamsters, tested one at a time, tended to stay close to the tube or in it. During...

Lucas, R. J., Allen, A. E., Brainard, G. C. et al. 2024. Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research. PLOS Biology 22(3), e3002535.

Light enables vision and exerts widespread effects on physiology and behavior, including regulating circadian rhythms, sleep, hormone synthesis, affective state, and cognitive processes. Appropriate lighting in animal facilities may support welfare and ensure that animals...

Lipp, H.-P., Krackow, S., Turkes, E. et al. 2024. IntelliCage: The development and perspectives of a mouse- and user-friendly automated behavioral test system. Frontiers in Behavioral Neuroscience 17.

IntelliCage for mice is a rodent home-cage equipped with four corner structures harboring symmetrical double panels for operant conditioning at each of the two sides, either by reward (access to water) or by aversion (non-painful...

Lindh, E., Meller, A., Raekallio, M. 2024. Effects of vatinoxan in rats sedated with a combination of medetomidine, midazolam and fentanyl. Acta Veterinaria Scandinavica 66(1), 23.

Alpha2-adrenoceptor agonists (α2-agonists) are widely used in animals as sedatives and for pre-anaesthetic medication. Medetomidine has often been given subcutaneously (SC) to rats, although its absorption rate is slow and the individual variation in serum...

Lima, A. F. de, Lima, S. G. C., Nogueira-Filho, S. L. G. et al. 2024. Object play as a positive emotional state indicator for farmed spotted paca (Cuniculus paca). Animals 14(1), 78.

We aimed to assess whether object play can be used as a positive emotional state indicator for farmed spotted pacas (Cuniculus paca) by examining its association with other positive welfare markers including affiliative behavior and...

Heuser, M., Gonzalez-Uarquin, F., Nuber, M. et al. 2024. A 3D-printed dummy for training distal phalanx amputation in mice. Animals 14(8), 1253.

The development of realistic dummies for training the distal phalanx amputation (DPA) technique in mouse pups is a promising alternative to reduce and replace animals in training for research and teaching. To test this, we...

Grigsby, K., Usmani, Z., Anderson, J. et al. 2024. Development and implementation of a Dependable, Simple, and Cost-effective (DSC), open-source running wheel in High Drinking in the Dark and Heterogeneous Stock/Northport mice. Frontiers in Behaviora

Maintaining healthy and consistent levels of physical activity (PA) is a clinically proven and low-cost means of reducing the onset of several chronic diseases and may provide an excellent strategy for managing mental health and...

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