Fillman-Holliday, D., Landi, M. S. 2002. Animal care best practices for regulatory testing. ILAR Journal 43(Supplement), S49-S58.

General discussion of environmental enrichment. Many laboratory animal species, especially dogs and nonhuman primates, lose interest and stop using a particular device after exposure to it for some time (authors' experiences). It is best to have an array of several differnt enrichmen devices available that can be alternated through the animal's environment to prevent boredom... Human interaction appears to be of little or no value for enriching the lives of mice. Regular handling of mice does seem to make them more docile.