Refinement Database

Database on Refinement of Housing, Husbandry, Care, and Use of Animals in Research

This database, created in 2000, is updated every four months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research.

Tips for using the database:

  • This landing page displays all of the publications in the database.
  • Use the drop-down menus to filter these publications by Animal Type, Setting, and/or Topic.
  • Clicking on a parent category (e.g., Rodent) will include publications relating to all the items in that category (e.g., Chinchilla, Gerbil, Guinea Pig, etc.).
  • You may also add a keyword to further narrow your search.
  • Please note that at this time, only publications dated 2010 or later (with some exceptions) can be filtered by Animal Type and Topic, and only publications dated 2020 or later (with some exceptions) can be filtered by Setting. Most publications older than 2010 can only be searched by keyword. 

Social housing has often been recommended as one‐way to address the psychological well‐being of captive non‐human primates. Published reports have examined methods to socialize compatible animals by forming pairs or groups. Successful socialization rates vary...

The act of grooming has been found to greatly decrease stress, heart rate, and cortisol levels in nonhuman primates; this decrease in stress and cortisol is seen in the animal being groomed, as well as...

Reviews of existing literature on topics that have been neglected, such as the subject of the cognitive and affective abilities of cows, are productive and necessary exercises in science (Elwen, Findlay, Kiszka, & Weir, 2011...

Domestic cows (Bos taurus) are consumed worldwide as beef and veal, kept as dairy product producers, employed as draft animals in labor, and are used for a long list of other products, including leather and...

Contentious issues in calf rearing include milk feeding level and single versus group housing. The current study was performed on a high-producing 170 Holstein cow dairy farm to investigate the impact of nutrition and housing...

Guinea pig pups produce typical distress whistles when isolated. Whistles’ frequency is decreased or abolished when they contact with the mother and, to a lesser degree, a sibling or even an unfamiliar female, is regained...

Rodents and primates deprived of early social contact exhibit deficits in learning and behavioural flexibility. They often also exhibit apparent signs of elevated anxiety, although the relationship between these effects has not been studied. To...

The study of laboratory animal behavior has increased steadily over the last decade, with expanding emphasis on a variety of commonly used species. In the United States, this trend was initially focused on species for...

The standard microisolation caging for guinea pigs, Cavia porcellus, allows for group housing up to a combined weight of 350 g. However, as mandated by the USDA, research facilities must socially house guinea pigs with...

Early social housing is known to benefit cognitive development in laboratory animals. Pre-weaned dairy calves are typically separated from their dam immediately after birth and housed alone, but no work to date has addressed the...

The question of whether it is better to house animals in groups rather than alone deals with the unresolved issues at the heart of animal welfare. In particular, we need to be able to rank...

Primates are notable for having a rich and detailed understanding of their social environment and there has been great interest in the evolution and function of social knowledge in primates. Indeed, primates have been shown...

This is the third volume of discussions that took place on the Laboratory Animal Refinement & Enrichment Forum (LAREF). This forum is dedicated to the exchange of personal experiences of refining the conditions under which...

Goat enrichment can be incredibly rewarding, not only for the goat, but for personnel as well. In our facility, we often refer to goatenrichment tasks as technician (or vet!) enrichment. Somewhere in the evolutionary development...

As a goat's separation from or reintegration into its group is likely to have an adverse effect on the welfare of both the separated goat and the remaining goats in the group, management procedures need...

We analyzed our current enrichment protocols in order to develop and implement social experiences for our rabbit and guinea pig colonies. This article describes the development of an exercise pen for rabbits and a custom-made...

Providing social housing that mimics the species' natural group composition should be an aim for all captive environments. Aotus are nocturnal, monogamist primates whose offspring (both male and female) disperse at sexual maturity, living solitarily...

Despite growing interest in promoting positive welfare, rather than just alleviating poor welfare, potential measures of good welfare, and means to provide it, have remained elusive. In humans social support improves stress-coping abilities, health, and...

The ideal animal model would contribute no confounding variables in experimental science. Variables affect experimental design resulting in increased animal use or repeated studies. We demonstrated a simple refinement which may reduce the number of...

This review will examine how individual differences in temperament might affect, or be affected by, behavioral management practices for captive primates. Measuring temperament may help us predict the outcome of social introductions. It can also...

Lean management-based visual tools have been used to improve the quality of animal care associated with a complex research study involving immune-compromised cynomolgus monkeys (M. fascicularis) in various postsurgical recovery states. In order to effectively...

There is a general consensus among those studying the welfare of captive primates that social housing is the most effective means for promoting psychological well-being. It is well established that socially-housed rhesus macaques (Macaca mulatta)...

Providing young animals the opportunity to engage in more complex social interactions is hypothesized to improve their capacity to cope with changing environments. To test the effects of the early social environment on the behavioral...

This study compared the effect of individual and pair housing and age at pair housing on the social behavior of young dairy calves. Twenty-seven pairs of calves were reared from birth until 6 wk either...

In captive research environments for nonhuman primates (NHP), social housing strategies are often in conflict with protocols designed to minimize disease transmission. This is particularly true in breeding colonies, and is especially relevant when attempting...