Humane Endpoint

Nwagwu, C. D., Defensor, E., Jiang, M. Y. et al. 2020. Endpoint in ovarian cancer xenograft model predicted by nighttime motion metrics. Lab Animal 49(8), 227–232.

Despite several therapeutics showing promise in nonclinical studies, survival from ovarian cancer remains poor. New technologies are urgently needed to optimize the translation of nonclinical studies into clinical successes. While most nonclinical settings utilize subjective...

Talbot, S. R., Biernot, S., Bleich, A. et al. 2020. Defining body-weight reduction as a humane endpoint: A critical appraisal. Laboratory Animals 54(1), 99–110.

In many animal experiments scientists and local authorities define a body-weight reduction of 20% or more as severe suffering and thereby as a potential parameter for humane endpoint decisions. In this study, we evaluated distinct...

National Research Council. 2009. Recognition and Alleviation of Pain in Laboratory Animals. The National Academies Press: Washington, DC, 198 pp.

Recognition and Alleviation of Pain in Laboratory Animals, the second of two reports revising the 1992 publication Recognition and Alleviation of Pain and Distress in Laboratory Animals from the Institute for Laboratory Animal Research (ILAR)...

Kliphuis, S. 2017. Humane Endpoints website huge success in Spain and the rest of the world. Laboratory Animals 51(2), 218-219.

The Humane Endpoints website (www.humane-endpoints.info) provides information and training modules on how to recognize humane endpoints in laboratory animals. This helps to prevent further distress in the animals by removing the animals from the experiment...