Mouse

Caron, A., Lelong, C., Pascual, M. H. et al. 2015. Miniaturized blood sampling techniques to benefit reduction in mice and refinement in nonhuman primates: Application to bioanalysis in toxicity studies with antibody-drug conjugates. JAALAS 5

Minimizing the number of animals in regulatory toxicity studies while achieving study objectives to support the development of future medicines contributes to good scientific and ethical practices. Recent advances in technology have enabled the development...

Read more about Caron, A., Lelong, C., Pascual, M. H. et al. 2015. Miniaturized blood sampling techniques to benefit reduction in mice and refinement in nonhuman primates: Application to bioanalysis in toxicity studies with antibody-drug conjugates. JAALAS 5

Wickremsinhe, E. R., Perkins, E. J. 2015. Using dried blood spot sampling to improve data quality and reduce animal use in mouse pharmacokinetic studies. JAALAS. 54(2), 139-144.

Traditional pharmacokinetic analysis in nonclinical studies is based on the concentration of a test compound in plasma and requires approximately 100 to 200 μL blood collected per time point. However, the total blood volume of...

Read more about Wickremsinhe, E. R., Perkins, E. J. 2015. Using dried blood spot sampling to improve data quality and reduce animal use in mouse pharmacokinetic studies. JAALAS. 54(2), 139-144.

Goto, T., Okayama, T., Toyoda, A. 2015. Strain differences in temporal changes of nesting behaviors in C57BL/6N, DBA/2N, and their F1 hybrid mice assessed by a three-dimensional monitoring system. Behavioural Processes 119, 86-92.

Nest building is one of the innate behaviors that are widely observed throughout the animal kingdom. Previous studies have reported specific brain regions and genetic loci associated with nest building in mice. These studies mainly...

Read more about Goto, T., Okayama, T., Toyoda, A. 2015. Strain differences in temporal changes of nesting behaviors in C57BL/6N, DBA/2N, and their F1 hybrid mice assessed by a three-dimensional monitoring system. Behavioural Processes 119, 86-92.

Lockworth, C. R., Kim, S., Liu, J. et al. 2015. Effect of enrichment devices on aggression in manipu

Agonistic behavior in group-housed male mice is a recurring problem in many animal research facilities. Common management procedures, such as the removal of aggressors, are moderately successful but often fail, owing to recurrence of aggressive...

Read more about Lockworth, C. R., Kim, S., Liu, J. et al. 2015. Effect of enrichment devices on aggression in manipu

Clipperton-Allen, A. E., Ingrao, J. C., Ruggerio, L. et al. 2015. Long-term provision of environmental resources alters behavior but not physiology or neuroanatomy of male and female BALB/c and C57BL/6 mice. JAALAS 54(6), 718-30.

Few studies have evaluated the long-term effects of providing environmental resources to mice. This consideration is important given that mice are often maintained in vivaria for months. We evaluated the effects of providing simple cage...

Read more about Clipperton-Allen, A. E., Ingrao, J. C., Ruggerio, L. et al. 2015. Long-term provision of environmental resources alters behavior but not physiology or neuroanatomy of male and female BALB/c and C57BL/6 mice. JAALAS 54(6), 718-30.

Miller, A., Kitson, G., Skalkoyannis, B. et al. 2015. The effect of isoflurane anaesthesia and buprenorphine on the mouse grimace scale and behaviour in CBA and DBA/2 mice. Applied Animal Behaviour Science 172, 58-62.

Prevention or alleviation of pain in laboratory mice is a fundamental requirement of in vivoresearch. The mouse grimace scale (MGS) has the potential to be an effective and rapid means of assessing pain and analgesic...

Read more about Miller, A., Kitson, G., Skalkoyannis, B. et al. 2015. The effect of isoflurane anaesthesia and buprenorphine on the mouse grimace scale and behaviour in CBA and DBA/2 mice. Applied Animal Behaviour Science 172, 58-62.

Kamakura, R., Kovalainen, M., Leppaluoto. J. et al. 2016. The effects of group and single housing and autom

Mice are used extensively in physiological research. Automated home‐cage systems have been developed to study single‐housed animals. Increased stress by different housing conditions might affect greatly the results when investigating metabolic responses. Urinary corticosteroid concentration...

Read more about Kamakura, R., Kovalainen, M., Leppaluoto. J. et al. 2016. The effects of group and single housing and autom

Spangenberg, E. M. F., Keeling, L. J. 2016. Assessing the welfare of laboratory mice in their home environment u

Welfare problems in laboratory mice can be a consequence of an ongoing experiment, or a characteristic of a particular genetic line, but in some cases, such as breeding animals, they are most likely to be...

Read more about Spangenberg, E. M. F., Keeling, L. J. 2016. Assessing the welfare of laboratory mice in their home environment u

Alves-Simoes, M., Coleman, G., Canal, M. M. 2016. Effects of type of light on mouse circadian behaviour and stress

Light is the principal synchronizing environmental factor for the biological clock. Light quantity (intensity), and light quality (type of light source) can have different effects. The aim of this study was to determine the effects...

Read more about Alves-Simoes, M., Coleman, G., Canal, M. M. 2016. Effects of type of light on mouse circadian behaviour and stress

Novak, J., Stojanovski, K., Melotti, L. et al. 2016. Effects of stereotypic behaviour and chronic mild stress on judgement bi

Cognitive processes are influenced by underlying affective states, and tests of cognitive bias have recently been developed to assess the valence of affective states in animals. These tests are based on the fact that individuals...

Read more about Novak, J., Stojanovski, K., Melotti, L. et al. 2016. Effects of stereotypic behaviour and chronic mild stress on judgement bi

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