Pain and its alleviation are currently a highly studied issue in human health. Research on pain and response to analgesia has evolved to include the effects of genetics, heritability, and sex as important components in...
The use of effective regimens for mitigating pain remain underutilized in research rodents despite the general acceptance of both the ethical imperative and regulatory requirements intended to maximize animal welfare. Factors contributing to this gap...
Ensuring that laboratory rodent pain is well managed underpins the ethical acceptability of working with these animals in research. Appropriate treatment of pain in laboratory rodents requires accurate assessments of the presence or absence of...
This second edition is fully revised, expanded, and comprehensively updated with the most current knowledge about the full array of mental health issues seen in animals. Written by key opinion leaders, internationally-recognized experts and specialists...
When mice are grouped together for the first time, it is a novel experience filled with new sights and smells that will stress the animal too much and may cause aggression. By adding a mirror...
‘Crunching’ is the term often used to describe the abnormal behaviour of mice that habitually crunch their pelleted diet, causing substrate levels to rise as the crumbs settle on the cage floor ultimately burying the...
Recent studies at Liverpool University have indicated that handling mice by their tails during routine cleaning and procedures induced aversion and high anxiety in many commonly used strains. The evidence from the Liverpool study suggests...
The author describes how she used an automated system to reduce how frequently mouse cage bedding is changed without compromising cleanliness. This idea came from the desire to reduce animal stress to a minimum.
Blood sampling is often performed in laboratory mice. Sampling techniques have the potential to cause pain, distress and impact on lifetime cumulative experience. In spite of institutions commonly providing guidance to researchers on these methods...
In many animal experiments scientists and local authorities define a body-weight reduction of 20% or more as severe suffering and thereby as a potential parameter for humane endpoint decisions. In this study, we evaluated distinct...