Mouse

Heuser, M., Gonzalez-Uarquin, F., Nuber, M. et al. 2024. A 3D-printed dummy for training distal phalanx amputation in mice. Animals 14(8), 1253.

The development of realistic dummies for training the distal phalanx amputation (DPA) technique in mouse pups is a promising alternative to reduce and replace animals in training for research and teaching. To test this, we...

Grigsby, K., Usmani, Z., Anderson, J. et al. 2024. Development and implementation of a Dependable, Simple, and Cost-effective (DSC), open-source running wheel in High Drinking in the Dark and Heterogeneous Stock/Northport mice. Frontiers in Behaviora

Maintaining healthy and consistent levels of physical activity (PA) is a clinically proven and low-cost means of reducing the onset of several chronic diseases and may provide an excellent strategy for managing mental health and...

Grandjean, J., Lake, E. M. R., Pagani, M. et al. 2024. What N Is N-ough for MRI-based animal neuroimaging? eNeuro 11(3), ENEURO.0531-23.2024.

Fueled by the recent and controversial brain-wide association studies in humans, the animal neuroimaging community has also begun questioning whether using larger sample sizes is necessary for ethical and effective scientific progress. In this opinion...

Dijkhuizen, S., Van Ginneken, L. M. C., IJpelaar, A. H. C. et al. 2024. Impact of enriched environment on motor performance and learning in mice. Scientific Reports 14(1), 5962.

Neuroscience heavily relies on animal welfare in laboratory rodents as it can significantly affect brain development, cognitive function and memory formation. Unfortunately, laboratory animals are often raised in artificial environments devoid of physical and social...

Arruda, I. F., Amendoeira, M. R. R., Bonifácio, T. F. et al. 2024. Humane endpoints in Swiss Webster mice infected with Toxoplasma gondii RH strain. Animals 14(9), 1326.

The highly virulent Toxoplasma gondii RH strain is maintained through successive passages in mice, but there is still a lack of studies that refine these procedures from a 3Rs perspective, where humanitarian ideals aim to...

Lawton, S. B., Grobe, C. C., Reho, J. J. et al. 2024. Differences in fluid, electrolyte, and energy balance in C57BL/6J mice (Mus musculus) in metabolic caging at thermoneutral or standard room temperatures. JAALAS 63(2), 190–200.

The Guide for the Care and Use of Laboratory Animals recommends mice be pair or group housed and provided with nesting materials. These provisions support social interactions and are also critical for thermoregulatory behaviors such...

Alamaw, E. D., Casey, K. M., Tien, K. et al. 2024. Carprofen attenuates postoperative mechanical and thermal hypersensitivity after plantar incision in immunodeficient NSG mice. Comparative Medicine 74(2), 105–114.

Immunodeficient NSG mice are reported to be less responsive to buprenorphine analgesia. Here, we used NSG mice to compare the efficacy of the commonly used dose of carprofen (5 mg/kg) with 5 and 10 times...

Benjamin, K. 2024. Make training easier with a scruffing restraint device. Laboratory Animal Science Professional 12(2) (March/April), 38-39.

If you conduct technical training with mice at your institution, a scruffing restraint device is a valuable addition to your training aid tool kit. A scruffing restraint device, such as the ScruffGuard offered by Research...

Walczak-Gillies, Matthews, O., Fyfe, A. et al. 2023. Refining the welfare of immunocompromised mice receiving carbon tetrachloride (CCI4) to induce liver fibrosis. Animal Technology and Welfare 22(3), 237–239.

Our method provides evidence that we can alter CCI4 dosing and implement recovery techniques to enhance Animal Welfare, whilst maintaining sufficient levels of fibrosis in the liver.

Rashbrook, V. S., Denti, L., Ruhrberg, C. 2023. Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia. Animal Welfare 32, e78.

Tamoxifen-induced CreER-LoxP recombination is often used to induce spatiotemporally controlled gene deletion in genetically modified mice. Prior work has shown that tamoxifen and tamoxifen-induced CreER activation can have off-target effects that should be controlled. However...

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