Rodent

Brogan, E., Kirchain, S. 2021. When to wean? A visual guide to Black, White, and Agouti mouse pup growth P14 – P28. Laboratory Animal Science Professional 9(3) (May/June), 46-48.

Laboratory mouse pups are commonly weaned between postnatal day 21–28. Utilization of an exact wean date postpartum is a concrete metric for mouse colony management, but variation can result such as: developmental differences among genetically...

Koch, A. L., Rusnak, M., Peachee, K. et al. 2021. Comparison of the effects of osmotic pump implantation with subcutaneous injection for administration of drugs after total body irradiation in mice. Laboratory Animals 55(2), 142-149.

The increasing potential for radiation exposure from nuclear accidents or terrorist activities has intensified the need to develop pharmacologic countermeasures against injury from total body irradiation (TBI). Many initial experiments to develop and test these...

Yatkin, E., Kulmala, N., Saukkonen, A. et al. 2021. A real-time health notification system aimed at enhancing the interaction between animal care staff and researchers promotes animal welfare. Laboratory Animals 55(3), 281-289.

Regardless of the microbiological status of an animal facility, research animals may experience health problems, leading to pain, suffering and distress. Simple and efficient tools are needed to collect data systematically, allowing researchers to react...

Ypsilantis, P., Souftas, V., Vyza, V. et al. 2021. Magnetic resonance imaging for early pregnancy diagnosis in the laboratory rat. Laboratory Animals 55(3), 262-269.

Pregnancy diagnosis and embryo counting are important end points in reproductive, developmental biology and toxicology studies. The purpose of the present study was to assess the feasibility and efficacy of magnetic resonance imaging (MRI) for...

Edwards, J., Olson, B., Marks, D.L. 2021. Constructing and programming a cost-effective murine running wheel with digital revolution counter. Lab Animal 50, 202-204.

Voluntary wheel running is a valuable metabolic intervention and well-established measure of physical activity in preclinical rodent models. Herein, we describe detailed assembly instructions and provide necessary resources for researchers to build their own running...

Krueger, L. D., Chang, S. E., Motoc, M. et al. 2021. Effects of pair housing on patency of jugular catheters in rats (Rattus norvegicus). JAALAS 60(3), 357-364.

Chronic vascular access devices are widely used in a variety of species for repeated blood sampling or substance administration. Jugular catheters are commonly used for studying addiction-related behaviors in rats. Rats with catheters have historically...

Xu, J. J., Thurston, S. E., Robinson, T. J. et al. 2021. Effects of analgesics on tumor growth in mouse models of prostate cancer bone metastasis. JAALAS 60(3), 341-348.

Murine models of tumor development often require invasive procedures for tumor implantation, potentially causing pain or distress. However, analgesics are often withheld during implantation because of concerns that they may adversely affect tumor development. Previous...

Blevins, C. E., Celeste, N. A., Marx, J. O. 2021. Effects of oxygen supplementation on injectable and inhalant anesthesia in C57BL/6 mice. JAALAS 60(3), 289-297.

Oxygen supplementation is rarely considered when anesthetizing laboratory mice, despite reports that mice become profoundly hypoxic under anesthesia. Little is known about the effects of hypoxia on anesthetic performance. This article focuses on the effects...

Voros, G. B., Dauchy, R. T., Myers, L. et al. 2021. Effects of daytime blue-enriched LED light on physiologic parameters of three common mouse strains maintained on an IVC system. JAALAS 60(3), 259-271.

Light has been a crucial part of everyday life since the beginning of time. Most recently, light-emitting diode (LED) light enriched in the blue-appearing portion of the visible spectrum (465 to 485 nm), which is...

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