Refinement Database

Database on Refinement of Housing, Husbandry, Care, and Use of Animals in Research

This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research.

Links to the full text for publications that appear in open access journals or are published on the AWI website are provided under the abstract.

Tips for using the database:

  • This landing page displays all of the publications in the database.
  • Use the drop-down menus to filter these publications by Animal Type and/or Topic.
  • Clicking on a parent category (e.g., Rodent) will include publications relating to all the items in that category (e.g., Chinchilla, Gerbil, Guinea pig, etc.).
  • You may also add a keyword to further narrow your search.
  • Please note that at this time, only publications dated 2010 or later (with some exceptions) can be filtered by Animal Type and Topic. Most publications older than 2010 can only be searched by keyword. 
In conclusion, the investigations carried out up to now demonstrate that during the early stages fish show high sensitivity to many types of stressors involving an array of responses to overcome alterations that could affect...
This 30-chapter volume informs students and professionals about the behavioral biology of animals commonly housed in laboratory and other captive settings. Each species evolved under specific environmental conditions, resulting in unique behavioral patterns, many of...
Blood sampling through the caudal vasculature is a widely used technique in fish biology for investigating organismal health and physiology. In live fishes, it can provide a quick, easy and relatively non‐invasive method for obtaining...
Triploid Atlantic salmon (Salmo salar) aquaculture has been extensively considered for many years, but its development has so far remained very limited. This is mostly due to poorer farming performances of triploid fish (3 N)...
This open access book is a printed edition of the Special Issue on Welfare of Cultured and Experimental Fishes that was published in the journal Fishes. The PDF is free for download.
The weekend effect hypothesis proposes that captive primates are more likely to give birth during times of low disturbance and reduced staff activity. The hypothesis specifically predicts that laboratory‐housed primates will be more likely to...
The Association of Primate Veterinarians (APV) recognizes that CSF collection may be required for both clinical and research purposes in nonhuman primates (NHP). Because there are inherent risks associated with the technique, the laboratory animal...
In this review, we focus primarily on the refinement of common methods used in fish research based on emerging knowledge with the aim of improving the welfare of fish used in scientific studies. We consider...
In the expanding salmon industry, many farmers use production methods that could result in poor welfare of the fish at various points of their lifecycle. We have reviewed methods used for producing salmon for food...
The ability to quickly and accurately determine cortisol as a biomarker for stress is a valuable tool in assessing the wellbeing of NHP. In this study, 2 methods of collecting saliva (a commercial collection device...
"Do any of you give cooked food like pasta, potatoes or vegetables to non-human primates? What’s your experience? Do the animals benefit from cooked food; do they like it; does it affect their health in...
This book summarizes the basic features of living fish. It is introduced by a chapter on the diversity of a group which has over 30,000 species, the largest within the vertebrates, describing the classification systems...
The success of breeding primates in captivity has led to a surplus number of animals in collections. This review examines published journals and key books to investigate the various methods of primate population control. Hormonal...
Over evolutionary time, light from the sun, moon, and stars has provided organisms with reliable information about the passage of time; but modern artificial lighting has drastically altered these cues. Evidence is accumulating that exposure...
Minimizing the number of animals in regulatory toxicity studies while achieving study objectives to support the development of future medicines contributes to good scientific and ethical practices. Recent advances in technology have enabled the development...
Sewage back-up and overflows in the rooms of our primate facility initiated an analysis of the factors contributing to the clogging of the drains. An investigation reviewing the materials responsible for the clogging of the...
This is the third volume of discussions that took place on the Laboratory Animal Refinement & Enrichment Forum (LAREF). This forum is dedicated to the exchange of personal experiences of refining the conditions under which...
Clinical Laboratory Animal Medicine: An Introduction, Fourth Edition offers a user-friendly guide to the unique anatomy and physiology, care, common diseases, and treatment of small mammals and nonhuman primates. Carefully designed for ease of use...
Since there is evidence that the bottom cages can impact research, this should be a good reason to eliminate the two-tier system with its species-inappropriate bottom-tier cages.
This review will examine how individual differences in temperament might affect, or be affected by, behavioral management practices for captive primates. Measuring temperament may help us predict the outcome of social introductions. It can also...
Lean management-based visual tools have been used to improve the quality of animal care associated with a complex research study involving immune-compromised cynomolgus monkeys (M. fascicularis) in various postsurgical recovery states. In order to effectively...
Wooden objects are often used as nonhuman primate enrichment to provide variety and novelty, promote exploratory behavior, and supply an outlet for curiosity. However, concerns have been raised regarding the ability to sanitize wood by...
In captive research environments for nonhuman primates (NHP), social housing strategies are often in conflict with protocols designed to minimize disease transmission. This is particularly true in breeding colonies, and is especially relevant when attempting...
The ability to provide permanent group-housed caging for nonhuman primates involved in toxicology research is quickly becoming an important step in improving the overall quality of life for these animals. This type of caging offers...
Refinement of animal care and housing is an important shared goal - and challenge - of the team of research, veterinary, and animal care personnel charged with ensuring the wellbeing of laboratory animals. This study...

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