Refinement Database

Database on Refinement of Housing, Husbandry, Care, and Use of Animals in Research

This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research.

Links to the full text for publications that appear in open access journals or are published on the AWI website are provided under the abstract.

Tips for using the database:

  • This landing page displays all of the publications in the database.
  • Use the drop-down menus to filter these publications by Animal Type and/or Topic.
  • Clicking on a parent category (e.g., Rodent) will include publications relating to all the items in that category (e.g., Chinchilla, Gerbil, Guinea pig, etc.).
  • You may also add a keyword to further narrow your search.
  • Please note that at this time, only publications dated 2010 or later (with some exceptions) can be filtered by Animal Type and Topic. Most publications older than 2010 can only be searched by keyword. 
Long-term, multi-institutional assessments have become a reliable tool for evaluating patterns of wounding in zoo-living primates, with results informing on best practices for species-specific care protocols and population management strategies. For western lowland gorillas (Gorilla...
Animal models of human diseases are important in biomedical research. When using animals for scientific purposes, the 3Rs (replace, reduce, refine) should be considered. Refinement of animal models is essential to ensure best use of...
Pain causes behavioral, autonomic, and neuroendocrine changes and is a common cause of animal welfare compromise in farm animals. Current societal and ethical concerns demand better agricultural practices and improved welfare for food animals. These...
Locomotion scoring is crucial for the early detection of lameness, which reduces sow welfare and performance. Our objective was to test the effectiveness of a visual analogue scale (VAS) to measure locomotory ability (OVERALL) compared...
Pig welfare is affected by housing conditions, the minimum requirements of which are set up by EU legislation. Animal and non-animal-based measures are useful indicators to investigate housing risk factors for pig welfare. An observational...
During the development of potential new medicines or agrochemicals, an assessment of the safety profile to humans and environmental species is conducted using a range of different in silico and in vitro techniques in conjunction...
The aim of this study was to investigate the impact of reduced stocking density in combination with provision of additional enrichment material on pig welfare on-farm. On three growing-finishing farms in Austria, in total 974...
Nowadays, most of the goat milk production in developed countries is done in intensive indoors production systems. In these systems, procedures such as disbudding are performed routinely. Disbudding is done in young goat kids and...
Environmental enrichment in pig housing is a legal requirement under current EU legislation, but some recommended loose materials may cause obstructions in fully-slatted systems. Wood is an organic material that could be compatible with slatted...
The objective of this study was to find a practical means of reducing pain associated with surgical castration by evaluating the effects of oral meloxicam and topical lidocaine, separately and in combination, on behavioral indicators...
Limited scientific literature is available for developing 'best practices' guidelines for the management of dairy goats (Caprus hircus), particularly goat kids. Disbudding practices for kids and calves appear to be similar, however, it is important...
We evaluated the effect of pain mitigation strategies (isoflurane and meloxicam) on the behaviour and physiology of 3-week-old disbudded goat kids. Fifty Saanen does (mean ± SD, 21 ± 3 days old) were randomly allocated...
The use of juvenile conventional pigs as a preclinical animal model to perform pharmacokinetic (PK), pharmacodynamic (PD) and safety studies for the paediatric population is increasing. Repetitive oral administration of drugs to juvenile pigs is...
This is the 5th volume of selected discussions that took place on the electronic Laboratory Animal Refinement & Enrichment Forum between February 2016 and December 2019. The forum was created in October 2002; it allows...
Litter sizes where piglets are supernumerary to teats leads to the practice of fostering to nurse sows or to artificial rearing systems, which is associated with compromised welfare. An alternative strategy is to leave the...
In this preliminary study, we compared changes in mechanical nociceptive thresholds (MNT) of calves and goat kids injected with clove oil or isoeugenol under the horn bud as a potential, more welfare-friendly alternative to hot-iron...
This experiment compared the stress responses of piglets to tail docking. Two hundred and eighty-eight piglets were allocated to the following treatments at 2 d post-farrowing: (1) sham handling treatment; (2) surgical castration; (3) tail...
The aim of this study was to develop and test a tilapia on-farm welfare assessment protocol, based on Brazilian semi-intensive production systems. The study included two mains steps: the elaboration of tilapia welfare protocol and...
The efficacy of analgesics such as meloxicam and ketoprofen to control pain in piglets when mixed with iron dextran (ID) before injection is unknown. The purpose of this study was to compare perceived pain in...
Analgesic products for piglet castration are critically needed. This requires extensive animal experimentation such as to meet regulatory-required proof of efficacy. At present, there are no validated methods of assessing pain in neonatal piglets. This...
According to the European Union Council Directive 2008/120EC, measures to minimise the risk for tail biting shall be taken before practicing tail docking, e.g. provision of manipulable material. Still, >90% of the pigs within EU...
It was the aim of the study to investigate the effect of a prolonged suckling period and group housing before weaning on tail biting in undocked nursery pigs. To do this, experiments with three treatment...
Surgical castration of piglets is a routine procedure on commercial pig farms, to prevent boar taint and reduce aggression. This procedure is known to cause pain, yet piglets are often not provided appropriate analgesia for...
Piglets on commercial pig farms are often tail-docked to reduce the incidence of tail-biting. While this is a painful procedure, piglets are often not provided analgesia or anaesthesia for pain relief. The objectives of this...
Tail biting in pigs is an animal welfare problem, and tail biting should be prevented from developing into tail damage. One strategy could be to predict events of tail biting so that the farmer can...

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