Refinement Database

Database on Refinement of Housing, Husbandry, Care, and Use of Animals in Research

This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research.

Links to the full text for publications that appear in open access journals or are published on the AWI website are provided under the abstract.

Tips for using the database:

  • This landing page displays all of the publications in the database.
  • Use the drop-down menus to filter these publications by Animal Type and/or Topic.
  • Clicking on a parent category (e.g., Rodent) will include publications relating to all the items in that category (e.g., Chinchilla, Gerbil, Guinea pig, etc.).
  • You may also add a keyword to further narrow your search.
  • Please note that at this time, only publications dated 2010 or later (with some exceptions) can be filtered by Animal Type and Topic. Most publications older than 2010 can only be searched by keyword. 

While non-human primate studies have long been conducted in laboratories, and more recently at zoological parks, sanctuaries are increasingly considered a viable setting for research. Accredited sanctuaries in non-range countries house thousands of primates formerly...

Emotional recognition has been demonstrated to occur between members of different species. However, the majority of studies on interspecific communication of emotions so far focused on the senses of vision and hearing while the contribution...

Rabbits are popular companion animals. There are numerous welfare issues affecting the majority of the population, including the fact that most rabbits are fearful when handled. Pet Remedy ™ (Unex Designs) is an herbal product...

This work provides an overview of the role of chemical communication in horse behavior and addresses the potential usefulness of this knowledge for management practices and animal welfare. First, we present an outline of the...

Dogs and cats use human emotional information directed to an unfamiliar situation to guide their behavior, known as social referencing. It is not clear whether other domestic species show similar socio-cognitive abilities in interacting with...

Pet rabbit welfare is a hidden crisis: Inappropriately housed, fed, and not routinely provided healthcare—rabbits can often suffer painful conditions and shortened lifespans. This study provides novel understanding of owners’ perceptions of rabbits’ mental capabilities...

A human–animal relationship can be developed through subsequent interactions, affected by the positive or negative emotional valence of the proceeding one. Horses implement a process of categorization to classify humans with whom they interact as...

In semi-natural mixed-sex groups, rabbits (Oryctolagus cuniculus) organize their social life by forming a hierarchy, which is characterized by linearity and stability. Compared to the natural environment, many factors are different in contemporary breeding systems...

Domestic animals often seek and enjoy interacting with humans. Positive human–animal relationships can elicit positive emotions and other positive welfare outcomes. Nevertheless, our understanding of the underlying processes that govern the positive perception of humans...

This is the 5th volume of selected discussions that took place on the electronic Laboratory Animal Refinement & Enrichment Forum between February 2016 and December 2019. The forum was created in October 2002; it allows...

The root cause of most welfare issues for horses is human behavior – people doing, or not doing, certain care, management or training practices. In addition, there is a gap between advancing scientific knowledge about...

Emotions are important for social animals because animals' emotions function as beneficial cues to identify valuable resources such as food or to avoid danger by providing environmental information. Emotions also enable animals to predict individuals'...

This article describes the importance of providing laboratory animals with opportunities to engage in play, and provides a few practical ideas for how to do this.

Body language is important for communication between individuals. Body language is based on the fact that the thought of performing a known action, alone, will activate the motor neurons used for the action, resulting in...

Neurophysiologic studies of NHP commonly involve their transfer from a housing enclosure to a laboratory by using a mobile chair. This transfer should be performed in a manner that is safe and minimizes stress for...

Care given to animals, such as grooming for horses, can be a source of well-being when carried out correctly. However, it can cause discomfort when badly perceived and lead to potentially dangerous reactions. This study...

Equine assisted interventions (EAIs) include all therapeutic interventions aimed at improving human wellbeing through the involvement of horses. Due to the prominent emotional involvement traditionally characterizing their relation with humans, horses developed sophisticated communicative skills...

Human body odors contain chemosignals that make species-specific communication possible. Interspecies communication studies were conducted on dogs and horses subjected to human chemosignals produced in happiness and fear emotional states. Dogs showed behaviors consistent with...

Body language is important for communication between individuals. Body language is based on the fact that the thought, alone of performing a known action will activate the motor neurons used for the action, resulting in...

In a randomized between-subjects design, we evaluated the effectiveness of each of three non-confrontational handling interventions compared to no intervention control on the behavior of horses during a single-trial simulated mildly aversive health care scenario...

Horse handlers often encounter problem behaviour resulting from a lack of stimulus control. Handlers are often only 15% of the weight of horses, which evolved strong flight responses. Therefore, many riders and handlers resort to...

Completely updated and revised, and with a new author team, this second edition of Farm Animal Behaviour continues to provide essential information on normal and stereotypic behaviors in a wide variety of farm animals to...

Human-animal bond is receiving increasing attention and is thought to confer benefits on well-being and performance in working animals. One important benefit of bonding is the “safe base” an attachment figure provides, which manifests in...

An understanding of the factors influencing the human-animal relationship is relevant in the development of welfare interventions for working equids. However, the link between the psychological attributes of animal owners, such as empathy level and...

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