Refinement Database

Database on Refinement of Housing, Husbandry, Care, and Use of Animals in Research

This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research.

Links to the full text for publications that appear in open access journals or are published on the AWI website are provided under the abstract.

Tips for using the database:

  • This landing page displays all of the publications in the database.
  • Use the drop-down menus to filter these publications by Animal Type and/or Topic.
  • Clicking on a parent category (e.g., Rodent) will include publications relating to all the items in that category (e.g., Chinchilla, Gerbil, Guinea pig, etc.).
  • You may also add a keyword to further narrow your search.
  • Please note that at this time, only publications dated 2010 or later (with some exceptions) can be filtered by Animal Type and Topic. Most publications older than 2010 can only be searched by keyword. 

Steroid-induced osteonecrosis of the femoral head (SONFH) is a condition documented in humans and animals exposed to chronic steroid administration. The rabbit has become a preferred animal model for investigating the pathogenesis and treatment of...

Confinement to farrowing crates is known to prevent sows from performing natural behavior, impairing animal welfare and possibly causing chronic stress. Hair cortisol analyses are increasingly used to detect chronic stress in animals. In the...

This study aimed to evaluate the agreement and reliability of the Feline Grimace Scale (FGS) among cat owners, veterinarians, veterinary students and nurses/technicians. Raters (n = 5/group) scored 100 images using the FGS (ear position, orbital tightening...

Dogs and cats have been extensively studied of late in relation to their paw preferences, with both species showing preferential motor bias at the level of the individual. Over the years, a wide range of...

Monitoring the vocalizations produced by livestock in commercial facilities can be used to remotely assess the arousal, and perhaps welfare, of the animals. Domestic swine is an ideal candidate for this type of assessment as...

Assessing how cats cope with the housing and husbandry at shelters is an important part of maintaining good animal welfare. There are non-invasive methods to assess how cats cope with their environment. The aim of...

This 30-chapter volume informs students and professionals about the behavioral biology of animals commonly housed in laboratory and other captive settings. Each species evolved under specific environmental conditions, resulting in unique behavioral patterns, many of...

The Animal Welfare Assessment Grid (AWAG) is a method for assessing quality of life, originally designed for experimental primates. This study adapts the AWAG for use in cattle and pigs, by adapting the factors included...

Posture changes in pigs during growth are often precursors of disease. Monitoring pigs’ behavioral activities can allow us to detect pathological changes in pigs earlier and identify the factors threatening the health of pigs in...

Animal models of human diseases are important in biomedical research. When using animals for scientific purposes, the 3Rs (replace, reduce, refine) should be considered. Refinement of animal models is essential to ensure best use of...

Measuring animal activity is useful for monitoring animal welfare in real time. In this regard, passive infrared detectors have been used in recent years to quantify piglet activity because of their robustness and ease of...

Pain causes behavioral, autonomic, and neuroendocrine changes and is a common cause of animal welfare compromise in farm animals. Current societal and ethical concerns demand better agricultural practices and improved welfare for food animals. These...

In order to assess the extent to which the legally prescribed training for the acquisition of animal experimentation expertise provides scientific personnel with the necessary competence and expertise to carry out a correct harm-benefit analysis...

Research to assess the relationship between cats and humans is in a nascent stage. Some studies have assessed the stress status in cats using physiological indicators, such as the cortisol hormone, but have not focused...

Several precision livestock farming (PLF) technologies, conceived for optimizing farming processes, are developed to detect the physical and behavioral changes of animals continuously and in real-time. The aim of this review was to explore the...

A species-specific composite pain scale is a prerequisite for adequate pain assessment. The aim of this study was to develop a multidimensional pain scale specific to rabbits (Oryctolagus cuniculus) called the Bristol Rabbit Pain Scale...

As pets are considered members of the family, their health has received widespread attention. Since pets cannot talk and complain when they feel uncomfortable, monitoring vital signs becomes very helpful in disease detection, as well...

We argue that there is currently an under-reporting of the ways in which pain can be associated with problem behavior, which is seriously limiting the recognition of this welfare problem. A review of the caseloads...

A guide for animal welfare assessment of fattening pigs recommends recording some of the indicators for a sample of the animals from a herd. However, it is not certain whether the herd’s level of welfare...

Pig cryptorchidism is a congenital anomaly, which requires surgical intervention. Pain assessment in pig farming has some limitations and consumers are increasingly concerned about suffering linked to on-farm procedures. The PGS seems to be a...

Respiratory diseases are a major problem in the pig industry worldwide. Due to the impact of these diseases, the early identification of infected herds is essential. Computer vision technology, using RGB (red, green and blue)...

The present study aimed at introducing a reliable and more feasible indicator to evaluate stereotypies in sows in comparison with the ‘Welfare Quality® animal welfare assessment protocol for sows and piglets’. Therefore, the indicators for...

The objective of this study was to find a practical means of reducing pain associated with surgical castration by evaluating the effects of oral meloxicam and topical lidocaine, separately and in combination, on behavioral indicators...

The purpose of this study was to evaluate whether linear and non-linear measures of heart rate variability (HRV) could be used as indicators of piglet castration pain. Thirty piglets were allocated to 1 of 4...

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