Refinement Database

Database on Refinement of Housing, Husbandry, Care, and Use of Animals in Research

This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research.

Links to the full text for publications that appear in open access journals or are published on the AWI website are provided under the abstract.

Tips for using the database:

  • This landing page displays all of the publications in the database.
  • Use the drop-down menus to filter these publications by Animal Type and/or Topic.
  • Clicking on a parent category (e.g., Rodent) will include publications relating to all the items in that category (e.g., Chinchilla, Gerbil, Guinea pig, etc.).
  • You may also add a keyword to further narrow your search.
  • Please note that at this time, only publications dated 2010 or later (with some exceptions) can be filtered by Animal Type and Topic. Most publications older than 2010 can only be searched by keyword. 
A negative human-animal relationship (HAR) from the perspective of the animal is a limiting factor affecting farm animal welfare, as well as farm animal productivity. Research in farm animals has elucidated sequential relationships between stockperson...
Owners may enhance their cats’ welfare by social enrichment (e.g. positive human-animal interactions), and physical enrichment (e.g. play objects). The purpose of this study was to investigate associations between owner characteristics (e.g. attitudes, attachment), household...
Reading books to shelter animals combining auditory enrichment with human presence is increasingly used although its effects on animal welfare have not yet been investigated. This study compared the behaviour of single-housed shelter dogs and...
The concept of the 3Rs (Refinement, Reduction and Replacement) has been used as a framework for improving the welfare of laboratory animals for the last half century. By establishing an animal-centric view on housing and...
The study of human–animal interactions has provided insights into the welfare of many species. To date, however, research has largely focused on human relationships with captive mammals, with relatively little exploration of interactions between humans...
Research to assess the relationship between cats and humans is in a nascent stage. Some studies have assessed the stress status in cats using physiological indicators, such as the cortisol hormone, but have not focused...
Visual communication involves specific signals. These include the different positions of mobile body elements. We analyzed visual configurations in cats that involve ears and the tail. We aimed at deciphering which features of these configurations...
Laboratory Animal Professionals experience many positive and rewarding interactions when caring for and working with research animals. However, these professionals also may experience conflicting feelings and exhaustion when the work is stressful due to factors...
We conducted a cross-sectional study to investigate the association between euthanasia and compassion fatigue among employees working in animal research at a large academic medical center. In summary, animal research workers who euthanize animals reported...
Positive stockperson attitudes to his or her animals is associated with a positive behavioural response in the animals and in other indicators assumed to reflect a high level of welfare as well as increased productivity...
Much environmental enrichment for laboratory animals is intended to enhance animal welfare and normalcy by providing stimulation to reduce 'boredom'. Behavioural manifestations of boredom include restless sensation-seeking behaviours combined with indicators of sub-optimal arousal. Here...
Throughout their evolutionary history, humans have tried to domesticate a variety of wild terrestrial mammals, resulting in a limited number that has been successfully domesticated. Among these domesticated species, domestic goats (Capra aegagrus hircus) are...
This is the 5th volume of selected discussions that took place on the electronic Laboratory Animal Refinement & Enrichment Forum between February 2016 and December 2019. The forum was created in October 2002; it allows...
Domestic animals are sensitive to human cues that facilitate inter-specific communication, including cues to emotional state. The eyes are important in signalling emotions, with the act of narrowing the eyes appearing to be associated with...
Gentling of cats in a shelter has been shown to increase contented behaviors and reduce anxiety, but it is not clear how gentling should be provided. Two experiments were conducted in cats confined to cages...
Guinea pigs are often involved in animal-assisted therapy (AAT) but there is little knowledge about the effects of human contact on guinea pigs involved in AAT. The aim of this study was to investigate effects...
Pet rabbit welfare is a hidden crisis: Inappropriately housed, fed, and not routinely provided healthcare—rabbits can often suffer painful conditions and shortened lifespans. This study provides novel understanding of owners’ perceptions of rabbits’ mental capabilities...
Recent studies demonstrated that cats form social bonds with both conspecifics and humans. One of the key factors regulating social interactions is the transfer of emotions between the individuals. The present study aimed at investigating...
Domestic animals often seek and enjoy interacting with humans. Positive human–animal relationships can elicit positive emotions and other positive welfare outcomes. Nevertheless, our understanding of the underlying processes that govern the positive perception of humans...
Temperament can be defined as interindividual differences in behavior that are stable over time and in different contexts. The terms ‘personality’, ‘coping styles’, and ‘behavioral syndromes’ have also been used to describe these interindividual differences...
Although the domestic cat (Felis catus) is probably the most widespread companion animal in the world and interacts in a complex and multifaceted way with humans, the human–cat relationship and reciprocal communication have received far...
This is a literature review of the effects of humans' relationships with farm animals on animal productivity and welfare, including the following topics: definition of the concept and description of different tests that have been...
Recent scientific evidence for fish sentience has stressed the need for novel sentience-based detection tools of fish welfare impairment in commercial farms. In order to mimic a well-characterised stress situation, rainbow trout (Oncorhynchus mykiss) were...
Zoological institutions often encourage cooperative interactions between keepers and animals so as to promote animals' welfare. One useful technique has been conditioning training, whereby animals learn to respond to keepers' requests, which facilitates a number...
The actions of human caretakers strongly influence animals living under human care. Here, we consider how intentional and unintentional signals provided by caretakers can inform our assessment of animals' well-being as well as help to...

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