Refinement Database

COST Action B-24 established four working groups to research and discuss issues relevant to laboratory animal science. These included the housing of animals, environmental needs, refinement of procedures, genetically modified animals, and cost-benefit analysis. Based...

To do justice to the diverse approaches to enrichment and behavioral management around the world would entail a discussion beyond the limits of this publication. Therefore, guidelines and regulations in a representative sample of countries...

It is now more than 20 years since both Council of Europe Convention ETS123 and EU Directive 86/609/EEC were introduced, to promote the implementation of the Three Rs in animal experimentation and to provide guidance...

These guidelines aim to provide information for investigators, animal care committees, facility managers and animal care staff that will assist in improving both the care given to farm animals and the manner in which experimental...

The regulation of the use of animals for experimental and other scientific purposes and the determination of minimum required standards of animal care and accommodation within Europe is generally informed by recommendations and conventions at...

In Japan, the Architectural Institute of Japan (AIJ) provides guidelines for laboratory animal facilities and equipment. Guidelines are not legally binding but serve as the authority for proper facilities and equipment management. The first guideline...

While strictly using positive reinforcement and applying patient gentle-firmness, most macaques can be trained to cooperate during the pole-attachment-chairing procedure. Some cannot be trained, because they have problems overcoming their often-legitimate mistrust of humans.

The German law on animal protection might be more utilitarian than the American law. The legislators obviously tried to meet the needs of the animals. However, its poor definitions of main concepts such as pain...

On the basis of this paper's conclusions (White et al., 1989), the USDA decreased their cage size requirements and removed the increased space requirement for breeding guinea pigs. How well did the study determine the...

This article provides details to consider when preparing to use animals in biomedical research. The stress of transport and receipt of animals into a new environment mandate the need for a period of stabilization and...

Non-human primates (NHPs) are utilized frequently in biomedical research and can be difficult and sometimes dangerous to handle. Because of this, restraint is sometimes necessary for data collection. Restraint chair training is generally a straightforward...

Since the 1998 publication of The Psychological Well-Being of Nonhuman Primates by the National Research Council, and the 1991 implementation of the 1985 Animal Welfare Act Amendment, many formal and informal nonhuman primate enrichment programs...

This article provides a brief historical background of the events and circumstances that led to the 1985 Animal Welfare Act (AWA) amendments. It describes the development of the regulations promulgated by the US Department of...

Federal welfare regulations for primates kept in research laboratories fail (1) to include recommendations pertaining to the legal requirement of the avoidance of stress and unnecessary discomfort during handling procedures, (2) to specify how the...

The USDA regulations pertaining to the minimum space requirements of nonhuman primates and the fitting of elevated resting surfaces are contradictory. They implicitly condone the prevailing perch design that allows maximal usage of animal room...

Expanding on the National Research Council’s Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of...

Many are critical of how regulatory testing practices have evolved and become established—critical both of the scientific rational and the animal welfare costs. The test of whether we are more enlightened than our predecessors will...

When attending veterinarians are not provided adequate job security by research institutions, there is no guarantee that they are reliable allies of nonhuman animals and implement the provisions set forth in the federal animal welfare...

If scientists are to have the privilege of being allowed to do painful experiments on animals, they must ensure that their experiments are beyond criticism.

Animals in the laboratory need the legally required "empty space" to meet their basic spatial requirements for postural adjustment, but they also deserve functional structured space for species-typical locomotor behavior and dynamic interaction with their...

The use of "pre-invasive" implantable radio telemetry has revolutionized the collection of physiological data under stress-free conditions. It is now possible to measure accurately 'normal' baseline data of haemodynamic and electrical parameters in conscious and...

Twenty-six reports provide detailed information of how primates can be trained to voluntarily cooperate - rather than resist - during blood collection, injection, topical drug application, blood pressure measurement, urine collection, and capture.

General guidelines for the housing, handling and behavioral management of laboratory animals, including nonhuman primates. Proper care, use, and humane treatment of animals used in research, testing, and education .. require scientific and professional judgment...

Published information provides scientific evidence that traditional, involuntary restraint techniques of research non-human primates are intrinsically a source of distress resulting from fear. It has been documented that common methods of enforced restraint result in...