Refinement Database

Database on Refinement of Housing, Husbandry, Care, and Use of Animals in Research

This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research.

Links to the full text for publications that appear in open access journals or are published on the AWI website are provided under the abstract.

Tips for using the database:

  • This landing page displays all of the publications in the database.
  • Use the drop-down menus to filter these publications by Animal Type and/or Topic.
  • Clicking on a parent category (e.g., Rodent) will include publications relating to all the items in that category (e.g., Chinchilla, Gerbil, Guinea pig, etc.).
  • You may also add a keyword to further narrow your search.
  • Please note that at this time, only publications dated 2010 or later (with some exceptions) can be filtered by Animal Type and Topic. Most publications older than 2010 can only be searched by keyword. 

Imaging is used in human medicine to diagnose disease and monitor treatment efficacy. Computed tomography (CT) positron emission tomography (PET) and magnetic resonance (MR) are applied to animal models of infectious diseases to increase data...

Rabbits are popular companion animals. There are numerous welfare issues affecting the majority of the population, including the fact that most rabbits are fearful when handled. Pet Remedy ™ (Unex Designs) is an herbal product...

Opioids are widely used in veterinary and human medicine to manage pain. However, there is a paucity of information in the literature regarding the pharmacokinetics of opioid transdermal patches (TDP) in NHP. Therefore, to determine...

Neurophysiologic studies of NHP commonly involve their transfer from a housing enclosure to a laboratory by using a mobile chair. This transfer should be performed in a manner that is safe and minimizes stress for...

Calvarial bone surgery on rabbits is frequently performed. This report aims to document a simple and practical anaesthetic and perioperative management for this procedure. Fourteen male New Zealand white rabbits were included in the study...

In an effort to enhance welfare, behavioural management continually refines methods of non-human primate (NHP) care. Chimpanzees (Pan troglodytes) are one of the most cognitively complex captive NHPs and they have been observed to self-medicate...

Rabbits are known to be finicky about food and will reject it based upon several factors: odor, texture, form, or method of presentation. It can be an even greater challenge to get rabbits to eat...

This study was designed to determine whether perineural injections of local anaesthetics decreases intraoperative nociception and improves postoperative analgesia in New Zealand White rabbits undergoing experimental stifle arthrotomy. All animals were anaesthetized using isoflurane and...

Among the many analgesic agents available, buprenorphine appears to be the analgesic used most often in rabbits. Unfortunately, deleterious side effects of opioids, such as gastrointestinal stasis and anorexia, may discourage the use of these...

Rhesus macaques (Macaca mulatta) are the most commonly used NHP biomedical model and experience both research and clinical procedures requiring analgesia. Opioids are a mainstay of analgesic therapy. A novel, transdermal fentanyl solution (TFS) has...

Medical care of nonhuman primates in a laboratory setting can be challenging due to the safety concerns inherent in handling conscious animals. A mature, adult male cynomolgus macaque presented with a chronic foot condition that...

The pole-and-collar method is one of several techniques that enable the safe transfer of a nonhuman primate from its home environment into a restraint chair without the need for sedation. It has been used within...

Captivity often limits a primate’s ability to make meaningful choices on a daily basis. Effective captive (behavioral) management programs should provide primates with opportunities to make meaningful choices. In the present study, arthritic chimpanzees were...

Traditional procedures for training nonhuman primates to be restrained in chairs typically involve very little use of positive reinforcement. In this talk, we detail a refined chair training procedure which uses a mix of positive...

The RSPCA/UFAW Rodent Welfare Group holds a one-day meeting every autumn so that its members can discuss current welfare research, exchange views on rodent welfare issues and share experiences of the implementation of the 3Rs...

Routine laboratory procedures can be stressful for laboratory animals. We wanted to determine whether human handling of adult rabbits could induce a degree of habituation, reducing stress and facilitating research-related manipulation. To this end, adult...

Traditional techniques used to capture New World monkeys, such as net capture, can induce high levels of acute stress detrimental to welfare. Alternatively, training nonhuman animals via operant conditioning to voluntarily participate in husbandry and/or...

The three main divisions of 'marmosetcare.com' aim respectively to promote: an understanding of the range of behaviour in this species, placing this behaviour in the context of its natural habitat and promoting good welfare in...

At the Oregon National Primate Research Center, we train animals to enter transfer boxes using positive reinforcement training (PRT), a type of training in which the trainer reinforces desired behaviors (such asentering the transfer box)...

The ability to provide permanent group-housed caging for nonhuman primates involved in toxicology research is quickly becoming an important step in improving the overall quality of life for these animals. This type of caging offers...

COST Action B-24 established four working groups to research and discuss issues relevant to laboratory animal science. These included the housing of animals, environmental needs, refinement of procedures, genetically modified animals, and cost-benefit analysis. Based...

The pole and collar method enables safe transfer of a monkey from their home environment to a restraint chair without sedation. The ability to conduct procedures with a conscious and cooperative subject is cost effective...

The discussion was started by the following questions: "Is the squeeze-back mechanism more or less stressful than the pole and collar system for removing a macaque from his cage for an IM (intramuscular) injection?" and...

While strictly using positive reinforcement and applying patient gentle-firmness, most macaques can be trained to cooperate during the pole-attachment-chairing procedure. Some cannot be trained, because they have problems overcoming their often-legitimate mistrust of humans.

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