Refinement Database

Database on Refinement of Housing, Husbandry, Care, and Use of Animals in Research

This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research.

Links to the full text for publications that appear in open access journals or are published on the AWI website are provided under the abstract.

Tips for using the database:

  • This landing page displays all of the publications in the database.
  • Use the drop-down menus to filter these publications by Animal Type and/or Topic.
  • Clicking on a parent category (e.g., Rodent) will include publications relating to all the items in that category (e.g., Chinchilla, Gerbil, Guinea pig, etc.).
  • You may also add a keyword to further narrow your search.
  • Please note that at this time, only publications dated 2010 or later (with some exceptions) can be filtered by Animal Type and Topic. Most publications older than 2010 can only be searched by keyword. 
Animal welfare is important for the humane treatment of animals under our care. Zoos and rescue centres manage various charismatic animals, such as big cats, with limited resources. It is therefore essential for caretakers to...
Extreme sunlight might be aversive to free-range laying hens, discouraging them from going outside. Range enrichment with artificial shelters may protect hens from sunlight and increase range use. The preferences of 34–40-week-old Hy-Line Brown laying...
Feather pecking remains a serious problem in poultry farming. This study aimed to identify risk factors for plumage damage as a proxy for feather pecking, and the predictive value of practical animal-based parameters. Data were...
As a global society, we have a duty to provide suitable care and conditions for farmed livestock to protect animal welfare and ensure the sustainability of our food supply. The suitability and biological impacts of...
Confinement and restriction of movement are a reality for most dairy cows. Providing outdoor access is one method to increase movement opportunities. However, leading cows to an outdoor exercise area increases their exposure to manipulations...
In dairy industry, quality of produced milk must be more important than quantity without a high somatic cells count (SCC) or pathogens causing mastitis of dairy cows and consumer diseases. Preserving the good health of...
In order to base welfare assessment of dairy cattle on real-time measurement, integration of valid and reliable precision livestock farming (PLF) technologies is needed. The aim of this study was to provide a systematic overview...
This study aimed to determine the prevalence of keel bone deviations and feather damage of laying hens in two different free-range housing systems under commercial conditions. Both of the free-range systems had an indoor barn...
Anticipatory behaviour occurs in the period before a reward or other positive event is presented and has been interpreted as an indicator of the welfare and emotional state of animals. The use of this indicator...
Societal concern with the welfare of egg laying hens housed in conventional cages is fostering a transition towards cage-free systems in many countries. However, although cage-free facilities enable hens to move freely and express natural...
Allowing dairy cattle to access pasture can promote natural behaviour and improve their health. However, the psychological benefits are poorly understood. We compared a cognitive indicator of emotion in cattle either with or without pasture...
Evaluation of animal behavior provides information on health and well-being in animals. In this preliminary study, we investigated the effectiveness of an accelerometry approach to evaluate changes in health status of cattle by combining physical...
The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is working with industry to promote social housing during cardiovascular telemetry recordings within non-rodent safety pharmacology and toxicology studies. Following surveys...
The concept of the 3Rs (Refinement, Reduction and Replacement) has been used as a framework for improving the welfare of laboratory animals for the last half century. By establishing an animal-centric view on housing and...
A partially (50%) perforated flooring system showed positive effects on health- and behavior-based welfare indicators without affecting production performance. Ammonia (NH3) is the most common air pollutant in poultry production, with effects on animal welfare...
Various pharmaceutical products have been derived from horse blood and urine for over a century. Production of biologics and therapeutics from these samples is a niche industry and often occurs in regions with little regulation...
Modern freestall barns for dairy cattle have been constructed with considerations for dairy cow cleanliness; partitions and other stall features such as neck rails are designed to reduce manure contamination of bedding and decrease farm...
The satisfaction of leisure horses’ behavioral needs has begun to be considered a priority, linked to the awareness that horses kept in single boxes may be deprived of social contact and the possibility to perform...
Due to a rising demand for goat milk and goat milk products worldwide, it is likely that dairy goat production will be intensified in the future, with larger herds per farm. In Switzerland, as in...
The study aimed to determine whether artificial shade influences grazing behavior and body weight of pregnant female red deer. Two groups of pregnant does were grazed in enclosures with shade (WS, n = 23), or non-shaded enclosures...
Climate change is a reality and global surface temperature is projected to rise substantially in the next 80 years. Agriculture practices will have to adapt to climate change, and also help to mitigate this effect...
The assessment and understanding of Absorption, Distribution, Metabolism and Elimination (ADME) for new pharmaceuticals is required in regulatory submissions. Typically, ADME studies are conducted using metabolism cages designed for the single housing of animals to...
We compared closed- and open-sided industrial houses with respect to the welfare of broiler chickens in southern Brazil. Ten flocks from each design were evaluated and measures divided into the following categories: i) bird health...
Background: Farm animals (FAs) are frequently used in biomedical research. Recommendations for the purchase, housing and health monitoring of these animals (sheep, goats, cattle and pigs) are still missing, and many institutes have developed their...
Ensuring good health and welfare is an increasingly important consideration for conservation of endangered species, whether free-ranging or managed to varying degrees under human care. The welfare-based design of a new habitat for Asian elephants...

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