Refinement Database

Database on Refinement of Housing, Husbandry, Care, and Use of Animals in Research

This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research.

Links to the full text for publications that appear in open access journals or are published on the AWI website are provided under the abstract.

Tips for using the database:

  • This landing page displays all of the publications in the database.
  • Use the drop-down menus to filter these publications by Animal Type and/or Topic.
  • Clicking on a parent category (e.g., Rodent) will include publications relating to all the items in that category (e.g., Chinchilla, Gerbil, Guinea pig, etc.).
  • You may also add a keyword to further narrow your search.
  • Please note that at this time, only publications dated 2010 or later (with some exceptions) can be filtered by Animal Type and Topic. Most publications older than 2010 can only be searched by keyword. 

In animal studies on bone healing, the effect of housing space and physical activity are seldom taken into account. Bone formation was evaluated in New Zealand White rabbits (mean ± SEM BW: 3.9 ± 0.11...

This is the 5th volume of selected discussions that took place on the electronic Laboratory Animal Refinement & Enrichment Forum between February 2016 and December 2019. The forum was created in October 2002; it allows...

In dogs, the social and spatial restriction associated with living in a kennel environment could lead to chronic stress and the development of abnormal behaviors (“kennel-dog syndrome”). However, little is known about how kenneled dogs...

Elizabethan collars are used in companion animals primarily to prevent self-trauma and associated negative welfare states in animals. However, they have been anecdotally associated with negative impacts on animal health and welfare including distress, abraded/ulcerated...

Domestic dogs experience a sensitive period for learning during early life and conditions during this time can have important consequences in the adult. We investigated the effects of kennel environment during early life, comparing the...

Pet rabbit welfare is a hidden crisis: Inappropriately housed, fed, and not routinely provided healthcare—rabbits can often suffer painful conditions and shortened lifespans. This study provides novel understanding of owners’ perceptions of rabbits’ mental capabilities...

The most widespread reproductive rhythm practiced in rabbit farming is based on artificial insemination (AI) performed at around 11 days pospartum. This approach results in high production rates, but requires high yearly replacement of animals...

As pets are considered members of the family, their health has received widespread attention. Since pets cannot talk and complain when they feel uncomfortable, monitoring vital signs becomes very helpful in disease detection, as well...

In Germany, an animal welfare ordinance for the housing of rabbits was issued which did not take into account the current investigations on floor design. The aim of the investigations was to study the effects...

Cage housing of growing rabbits is associated with welfare concerns. An alternative system that has already been introduced involves pens with non-wire floors. An important aspect of group pens, for which the best solution has...

The confined environment of the dog shelter, particularly over extensive time-periods can impact severely on welfare. Surveillance and assessment are therefore essential components of the welfare protocol. The aim of this study was to generate...

The RSPCA/UFAW Rodent (and now Rabbit) Working Group has held a one-day meeting every autumn for the last 25 years, so that its members can discuss current welfare research, exchange views on welfare issues and...

The aim of the present study was to develop and evaluate a new housing system for fattening rabbits. Data were collected on a farm with rabbits housed either under new conditions (NC) or established (conventional)...

We evaluated the effects of two types of colony cages, in which rabbit does were always in a group (C1), and where they were in combi cages furnished with removable internal walls to allow both...

A three-week enrichment preference study trialling different substrates, food and pen structures was carried out in three, group-housed female New Zealand White Rabbits (NZW). Preference results: structural - rabbits spent the most time with a...

At Envigo we are contracted by our customers to conduct studies, usually to evaluate the safety of new drugs and chemicals. A rodent and non-rodent species are usually involved in this testing with the method...

The RSPCA/UFAW Rodent (and now Rabbit) Welfare Group held a one-day meeting on 14 November 2017 in Weybridge, UK. The first session addressed meeting animals' needs and aiming for a 'good life', with the needs...

Evaluation of kennel flooring surfaces is needed to understand their impacts on dog health and well-being. This pilot study aimed to characterize aspects of physical health, kennel cleanliness, and dog body cleanliness on flooring types...

Greyhounds are routinely bred and managed for racing and are usually housed in individual kennels. To address the question of whether greyhounds would benefit from an increase in the minimum kennel size specified in the...

This study describes a refined/modified vest and jacket worn by dogs to capture ECG data after they are given a compound of interest. The modified vest and jacket prevents dogs from chewing the leads and...

The aim of this work was to study how the group size and the number of doorways in a pen may influence the aggressive interactions throughout the reproductive cycle among does kept in a part-time...

Although the number of rabbits (Oryctolagus cuniculus) produced in Europe is important, they are under-represented in welfare research. Studies on the effects of housing conditions have focused on performance and mortality. We conducted a meta-analysis...

Dogs are individually housed when collecting data for ECG studies to avoid any cross talk between transmitted signals (generally for a 24 hour recording period). Each implant is set at a certain frequency which transmits...

Rabbits are gregarious animals that live in social groups in the wild so individually housing our animals, while meeting the present scientific objectives, restricts their natural social behaviour. How to meet the social needs of...

In order to provide research dogs enrichment at our facility, veterinary staff suggested adapting the adjacent space to our dog housing buildings to allow for more species-specific behavior by creating an exercise area that both...

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